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Literature summary extracted from

  • Tong, L.; Pav, S.; Mui, S.; Lamarre, D.; Yoakim, C.; Beaulieu, P.; Anderson, P.C.
    Crystal structures of HIV-2 protease in complex with inhibitors containing the hydroxyethylamine dipeptide isostere (1995), Structure, 3, 33-40.
    View publication on PubMed

Application

EC Number Application Comment Organism
3.4.23.47 medicine potential target for chemotherapy of virus infection and associated diseases, essential for maturation of infectious virions, development of drugs against the protease should be effective against HIV-2 Human immunodeficiency virus 2

Cloned(Commentary)

EC Number Cloned (Comment) Organism
3.4.23.47
-
 Human immunodeficiency virus 2

Crystallization (Commentary)

EC Number Crystallization (Comment) Organism
3.4.23.47 crystallized by hanging drop method in complex with a reduced amide inhibitor, BI-LA-398 Human immunodeficiency virus 2
3.4.23.47 crystals grown by hanging-drop vapor diffusion method, thin tetragonal prisms, space group P4(1)2(1)2 or P4(3)2(1)2 with a=b=62.6 A and c=115.8 A Human immunodeficiency virus 2

Inhibitors

EC Number Inhibitors Comment Organism Structure
3.4.23.47 2,6-dimethylbenzyl (2S,3R)-4-((2S,4R)-2-(tert-butylcarbamoyl)-4-(4,6-dimethylpyrimidin-2-ylthio)piperidin-1-yl)-3-hydroxy-1-phenylbutan-2-ylcarbamate hydroxyethylamine dipeptide isostere inhibitor 3 Human immunodeficiency virus 2
3.4.23.47 2,6-dimethylbenzyl (2S,3R)-4-((2S,4R)-2-(tert-butylcarbamoyl)-4-(pyridin-3-ylmethoxy)piperidin-1-yl)-3-hydroxy-1-phenylbutan-2-ylcarbamate hydroxyethylamine dipeptide isostere inhibitor 5 Human immunodeficiency virus 2
3.4.23.47 2,6-dimethylbenzyl (2S,3R)-4-((2S,4R)-2-(tert-butylcarbamoyl)-4-(pyridin-3-ylthio)piperidin-1-yl)-3-hydroxy-1-phenylbutan-2-ylcarbamate hydroxyethylamine dipeptide isostere inhibitor 2 Human immunodeficiency virus 2
3.4.23.47 2,6-dimethylbenzyl (2S,3R)-4-((2S,4R)-2-(tert-butylcarbamoyl)-4-(pyridin-4-ylsulfonyl)piperidin-1-yl)-3-hydroxy-1-phenylbutan-2-ylcarbamate hydroxyethylamine dipeptide isostere inhibitor 4 Human immunodeficiency virus 2
3.4.23.47 2,6-dimethylbenzyl (2S,3R)-4-((2S,4R)-2-(tert-butylcarbamoyl)-4-(pyridin-4-ylthio)piperidin-1-yl)-3-hydroxy-1-phenylbutan-2-ylcarbamate hydroxyethylamine dipeptide isostere inhibitor 1 Human immunodeficiency virus 2
3.4.23.47 N-((S)-1-((2S,3R)-4-((2S,4R)-2-(tert-butylcarbamoyl)-4-(pyridin-3-ylmethoxy)piperidin-1-yl)-3-hydroxy-1-phenylbutan-2-ylamino)-3-methyl-1-oxobutan-2-yl)quinoline-2-carboxamide hydroxyethylamine dipeptide isostere inhibitor 8 Human immunodeficiency virus 2
3.4.23.47 N-((S)-1-((2S,3R)-4-((2S,4R)-2-(tert-butylcarbamoyl)-4-(pyridin-3-ylmethylthio)piperidin-1-yl)-3-hydroxy-1-phenylbutan-2-ylamino)-3-methyl-1-oxobutan-2-yl)quinoline-2-carboxamide hydroxyethylamine dipeptide isostere inhibitor 6 Human immunodeficiency virus 2
3.4.23.47 N-((S)-1-((2S,3R)-4-((2S,4R)-2-(tert-butylcarbamoyl)-4-(pyridin-3-ylthio)piperidin-1-yl)-3-hydroxy-1-phenylbutan-2-ylamino)-3-methyl-1-oxobutan-2-yl)quinoline-2-carboxamide hydroxyethylamine dipeptide isostere inhibitor 7 Human immunodeficiency virus 2

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
3.4.23.47 GAG precursor protein of HIV-2 + H2O Human immunodeficiency virus 2
-
 ?
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
3.4.23.47 Human immunodeficiency virus 2
-
 human immunodeficiency virus type 2
-

Purification (Commentary)

EC Number Purification (Comment) Organism
3.4.23.47
-
 Human immunodeficiency virus 2

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.4.23.47 GAG precursor protein of HIV-2 + H2O
-
 Human immunodeficiency virus 2 ?
-
 ?
3.4.23.47 additional information catalyzes hydrolysis of Phe-Pro, Tyr-Pro and other peptide bonds in the gag and gag-pol polyproteins Human immunodeficiency virus 2 ?
-
 ?

Subunits

EC Number Subunits Comment Organism
3.4.23.47 dimer 2 identical subunits, homodimer Human immunodeficiency virus 2